Titular professor at the Centre for Advanced Studies and Research of the National Polytechnic Institute of Mexico, he is one of the most prestigious neurophysiologists in the international community. He has made important contributions to the field of neurophysiology. Is main interest centres upon the study of the pre-synaptic mechanisms which control synaptic transmission in the spinal cords of vertebrae. In this context, Dr Rudomín and his group have analyzed in great detail the functional organisation of the segmented and supraspinal pathways which regulate the synaptic efficacy of different types of sensorial fibres coming from skin and muscle receptors.
After beginning his studies at the National School of Biological Sciences. he became interested in research at the hands of Ramón Álvarez-Buylla, a citizen of Oviedo who had emigrated to Mexico. Rudomín cooperates as a member of the Editorial Committee of many of the most important journals in the field of neurophysiology, among others, "Journal of Neurophysiology", "Brain Research", "Experimental Brain Research", "Neuroscience Letters" and "Neuroscience Research".
He has also given a great many lectures in various research centres in his country and abroad and has been a visiting lecturer at the Rockerfeller University, the Marine Biomedical Institute and the National Health Institutes (United States), the Sienna Institute of Medical Pathology (Italy), the Hebrew University of Jerusalem and Götheborg University (Sweden). In 1984 he was the appointed the Fogarty Scholar in residence at the National Health Institutes in the United States.
His scientific contributions have won him recognition such as the Natural Sciences Award of the Mexican Academy of Scientific Research in 1972, and, in 1979, the National Science Award, the highest distinction granted by the Mexican government.
Apart from his outstanding work as a researcher, Pablo Rudomín has carried out teaching work of great quality, having trained in his laboratories neurophysiologists who now work all over the world. Between 1975 and 1981 he worked as the Executive Spokesman of National Basic Science Programme of the Mexican National Council for Science and Technology, a programme established to a large extent by Rudomín himself to support scientific research in his country. He also chaired the Mexican Academy of Scientific Research from 1981 to 1983. In 1986 he was appointed as a member of a group of neurobiology advisors for the U.S. National Institutes of Health, and that same year, together with his co-researchers, he obtained the Medal of the Mexican Academy of Scientific Research for the best work in Biomedical Science. From 1989 on he was appointed as a member of the Science Advisory Council of the President of the Republic. In 1989 he received the Elizondo prize, granted by the Monterrey Technology Institute for the importance of his scientific work.